Inflammatory Bowel Disease in Africa

Posted by samuelkurnianta On Tuesday, January 29, 2013 2 comments

Inflammatory Bowel Disease

Bowel disease, which has killed up to 45 percent of those infected, it can be found throughout sub-Saharan Africa, according to Chinyere Okoro from the Wellcome Trust Sanger Institute in the UK.

He said, "It's an infectious disease, which is found in the bloodstream and can affect other organs in the body of the patient. The disease is caused by bacteria called Salmonella Typhimurium. Sometimes, Salmonella Typhimurium in healthy people usually cause gastroenteritis, of which one symptom is diarrhea. So, most people will not require hospital treatment.

According Okore, Salmonella Typhimurium causing disease is not the same as gastroenteritis. More like typhus in those whose immune system is weak. "I mean, people with weak immune systems are the immunocompromised by disease. In this case, generally HIV and in children, which is now contracting malaria or malnutrition, "he added.

This disease spreads rapidly and can kill within days. Okoro said people who receive anti-retroviral drug therapy or ART, for HIV transmission, it is not easily contracted Salmonella Typhimurium.

"With proper treatment, a person's immune system would not be weakened to attack a vulnerable stage of the disease. So, if available ART, we expect the rate of transmission and the attack by the disease lessened, "he said.

DNA analysis showed the bacteria first appeared in two waves. The first occurred about 50 years ago in southeast Africa, and the next about 35 years ago, probably from the Congo Basin. This is similar to the route of HIV.

According to Okoro, originally it was a transmission that occurs in HIV positive. Now, the disease was lodged in the body of people with untreated HIV. Within a decade, the disease was initially treated antibiotic chloramphenicol. However, the bacteria quickly become resistant to the drug so it would accelerate the spread of the disease among HIV positive.

Okoro said the disease can be treated with antibiotics newer, more powerful and more expensive if available. Thus, treatment of HIV positive people in Africa with ARVs can help stem the spread of intestinal diseases that. The same applies to the treatment of malaria and better nutrition for children.

Path of transmission is not known for sure, but said Okoro, right now, it seems the disease does not spread through the food chain.


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